Kristen Bortke, Shay Cook, Brandi Davidson, Shawna Dietz, Lenae Schneider, & Jordan Taghon

For causes unknown, though speculated to be an alteration in the immunological and vascular systems, there is an overproduction of collagen. Collagen, a protein, is basically a large component of connective tissue that provides the structure and support of the body, allowing strength and elasticity. When an overproduction of collagen occurs, the affected organ (which may include: skin, stomach, blood vessels, esophagus) hardens and tightens, thus concluding in a reduction of motility, function, and effectiveness. This is due to the fact that there is an excess collagen production which leads to fibrosis, a scarring and thickening of connective tissue, which can impair blood flow to an area or make it difficult for the organ to work effectively, like fibrosis of the esophagus may impair swallowing.